Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome
نویسندگان
چکیده
منابع مشابه
Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome
Expression of type 5 phosphodiesterase (PDE5), a cGMP-specific hydrolytic enzyme, is frequently altered in human cancer, but its specific role in tumorigenesis remains controversial. Herein, by analyzing a cohort of 69 patients affected by glioblastoma multiforme (GBM) who underwent chemo- and radiotherapy after surgical resection of the tumor, we found that PDE5 was strongly expressed in cance...
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1 Penn State Institute of the Neurosciences and Penn State Cancer Institute, Hershey, PA 17033, USA 2The Ohio State University College of Medicine, Columbus, OH 43210, USA 3Departments of Health Evaluation Sciences and Neurosurgery, Penn State College of Medicine/Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA 4Radiation Oncology Brain Tumor Laboratory, University of Alabama...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.14656